Although this is not new news (released November 2006 I think), I'd like to point out how cool having Python run ASP.NET is. I don't actually know how to program python...yet...but programming Python appears intuitive be nature.
To get an HelloWorld IronPython ASP.NET application running, it took me all of about 5 minutes, 3 to download and install the add-in, 1 to open Visual Studio, then another minute to type in some stuff and run it. Sweet. At this point the intellisense has nothing of your other standard languages like C#, but I'm sure that's coming.
One of the biggest issues I see with a a large number of languages is a good IDE. Not to say that Python doesn't already have a number of good IDEs, but, I haven't used an IDE yet that actually beats Visual Studio. So since IronPython can make the effort to actually integrate with Visual Studio and be compatible with all my existing .NET libraries, maybe I'll just have to make more of an effort to check it out.